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ea0047oc4 | Spotlight on Neuroendocrine tumours | Theranostics2016

68Ga, 64Cu labelling and affinity study of NODAGANOC, a NODAGA conjugated somatostatin analogue

Azzouna Rana Ben , Al-Shoukr Faisal , Hyafil Fabien , Rouzet Francois , Guilloteau Denis , Le Guludec Dominique

Introduction: DOTANOC is a largely used somatostatin analogue in NETs investigations. In NODAGANOC, the DOTA is replaced by NODAGA, a chelator derivative from NOTA which is the ‘gold standard’ for Ga3+ and Cu2+ chelation because it forms more stable complexes than DOTA.[1] The aim of our study is to evaluate the affinity of NODAGANOC for somatostatin receptors (sst) and to develop a 68Ga and 64Cu labelled NODAGANOC for a fu...